Abstract
Aim: Chronic hypoxemic respiratory failure may develop due to lung damage in patients with severe COVID-19 infection. Therefore, chronic respiratory failure that requires continuous oxygen support may develop. The aim of this study is to evaluate the effect of using oxygen concentrators on oxygen saturation after coronavirus disease 2019 (COVID-19) infection.
Material and Method: The study included 42 patients who used oxygen concentrators and 66 patients who did not use concentrators and applied to Ankara Training and Research Hospital Pulmonology Outpatient Clinic between January 1, and April 8, 2021 after COVID-19 infection. Patients received a sociodemographic data questionnaire and a COVID-19 infection severity questionnaire, which were completed through face-to-face interviews. Patients’ oxygen saturation levels were also measured and recorded at the time of interview.
Results: Those using oxygen concentrators were older and had less education (p=0.001; p=0.03, respectively). Patients who complained of shortness of breath during infection were mostly in the oxygen concentrator group, while those who had headaches and diarrhoea were mostly in the group that did not require concentrators. The group using oxygen concentrators had longer hospital stays due to COVID-19 infection (p=0.001). Patients using oxygen concentrators had higher rates of pulmonary involvement and lower oxygen saturation levels (p=0.001).
Conclusion: Patients who complained of dyspnea at the time of their COVID-19 diagnosis were more likely to require a concentrator at a later stage. Other factors influencing the need for concentrators include advanced age and education level. Patients using an oxygen concentrator had lower oxygen saturation levels, but the mean value was higher.
Keywords
Ethical Statement
The study received permission from the Republic of Türkiye Ministry of Health COVID-19 Scientific Research Review Committee. Ethical approval was obtained from the University of Health Sciences Ankara Training and Research Hospital, Clinical Research Ethics Committee on December 30, 2020 (Desicion no: 519/2020).
Supporting Institution
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Project Number
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Thanks
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References
- 1. Habas K, Nganwuchu C, Shahzad F, et al. Resolution of coronavirus disease 2019 (COVID-19). Expert Rev Anti Infect Ther 2020;18(12):1201-11.
- 2. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of Coronavirus disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782-93
- 3. Rostami A, Sepidarkish M, Leeflang M, et al. SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis. Clin Microbiol Infect 2021;27(3):331-40.
- 4. Yalçın A. COVID-19 sürecinde yoğun bakım yönetimi. Review. Medical Research Reports. 2020;3(2):66-85.
- 5. Jiang B, Wei H. Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients. Eur Rev Med Pharmacol Sci 2020;24(19):10239-46.
- 6. Dhont S, Derom E, Van Braeckel E, Depuydt P, Lambrecht BN. The pathophysiology of 'happy' hypoxemia in COVID-19. Respir Res 2020;21(1):198.
- 7. Mo X, Jian W, Su Z, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020;55(6):2001217.
- 8. Endeman H, van der Zee P, van Genderen ME, van den Akker JPC, Gommers D. Progressive respiratory failure in COVID-19: a hypothesis. Lancet Infect Dis 2020;20(11):1365.
- 9. Bellan M, Soddu D, Balbo PE, et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA Netw Open 2021;4(2):e2036142.
- 10. Ekbom E, Frithiof R, Emilsson Öi, et al. Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge. Respir Med 2021;182:106394.
- 11. Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;397(10270):220-32.
- 12. Truffaut L, Demey L, Bruyneel AV, et al. Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission. Respir Res 2021;22(1):29.
- 13. Balbi M, Conti C, Imeri G, et al. Post-discharge chest CT findings and pulmonary function tests in severe COVID-19 patients. Eur J Radiol 2021;138:109676.
- 14. Steinbeis F, Thibeault C, Doellinger F, et al. Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months. Respir Med 2022;191:106709.
- 15. Sundh J, Palm A, Wahlberg J, Runold M, Ekström M. Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in Sweden. PLoS One 2022;17(4):e0266367.
- 16. Ismail J, Bansal A. Medical oxygen: A lifesaving drug during the COVID-19 pandemic-source and distribution. Indian J Pediatr 2022;89(6):607-15.
- 17. Arora A, Hasan MMF. Flexible oxygen concentrators for medical applications. Sci Rep 2021;11(1):14317.
- 18. Zorlu D. Is the use of home-type respiratory support devices effective? J DEU Med 2021;35(2):201-17.
- 19. Nowadly CD, Portillo DJ, Davis ML, Hood RL, De Lorenzo RA. The use of portable oxygen concentrators in low-resource settings: A Systematic Review. Prehosp Disaster Med 2022;37:247-54.
- 20. Kvale PA, Conway WA, Coates EO. Nocturnal Oxygen Therapy Trial Group. Continuous or Nocturnal Oxygen Therapy in Hypoxemic Chronic Obstructive Lung Disease: A Clinical Trial. Ann Intern Med 1980;93(6):391-8.
- 21. Ringbaek TJ, Viskum K, Lange P. Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease? Eur Respir J 2002;20(1):38-42.
- 22. Stuart Harris C, Bishop J, Clark TJH, et al. Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1981;1(8222):681-6.
- 23. Düzenli H, Doğan ÖT, Berk S, Özşahin SL, Akkurt İ. Kronik solunum yetmezliği olan olgularda uzun süreli oksijen tedavisinin yaşam süresi üzerine etkisi. Tuberk Toraks 2008;56(2):179-86.
- 24. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708-20.
- 25. Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: A review. Radiography (Lond) 2021;27(2):682-7.
- 26. Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19. N Engl J Med 2020:17;383(25):2451-60.
- 27. Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using Open SAFELY. Nature 2020 Aug;584(7821):430-6.
- 28. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-62.
- 29. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
Abstract
Amaç: Çalışmamızda COVID-19 enfeksiyonu sonrası oksijen konsantaratörü
kullanımının oksijen satürasyonlarına etkisini değerlendirmek amaçlanmıştır.
Gereç ve Yöntem: Ankara Eğitim ve Araştırma Hastanesi Göğüs Hastalıkları
polikliniğine 01.01.2021-08.04.2021 tarihleri arasında COVID-19 enfeksiyonu
sonrasında başvuran, oksijen konsantratörü kullanan 42 hasta ile konsantratör
kullanmayan 66 hasta çalışmaya dahil edildi. Katılımcılara; sosyodemografik veri
formu ile COVID-19 enfeksiyonu şiddetini belirlemeyi amaçlayan sorulardan oluşan
anket formu yüz yüze uygulandı ve hastaların o anki oksijen satürasyonları ölçülerek
kaydedildi.
Bulgular: Oksijen konsantratörü kullananların ileri yaşta ve eğitim seviyesinin
düşük olduğu görüldü (sırasıyla p=0.001; p=0.03). Enfeksiyon döneminde nefes
darlığı şikayeti olan hastaların daha çok oksijen konsantratörü kullanan grupta
olduğu; baş ağrısı ve ishal semptomları yaşayan hastaların ise konsantratör ihtiyacı
olmayan grupta istatistiksel anlamlı olarak daha çok olduğu görüldü. COVID-19
enfeksiyonuna bağlı hastanede yatış süresi oksijen konsantratörü kullanan grupta
daha yüksek bulundu (p=0.001). Oksijen konsantratörü kullanan hastalarda akciğer
tutulumunun daha fazla ve oksijen satürasyonlarının daha düşük olduğu görüldü
(p=0.001).
Sonuç: Çalışmamızda oksijen konsantratörü kullanan hastaların hastanede yatış
süresi ve akciğer tutulumu daha fazlaydı. COVID-19 tanısı sırasında nefes darlığı
şikayeti olan hastaların ilerleyen süreçte konsantratöre daha çok ihtiyaç duyduğu
görüldü. İleri yaş ve eğitim seviyesi de konsantratör ihtiyacını etkilemekteydi.
Keywords
Project Number
-
References
- 1. Habas K, Nganwuchu C, Shahzad F, et al. Resolution of coronavirus disease 2019 (COVID-19). Expert Rev Anti Infect Ther 2020;18(12):1201-11.
- 2. Wiersinga WJ, Rhodes A, Cheng AC, Peacock SJ, Prescott HC. Pathophysiology, transmission, diagnosis, and treatment of Coronavirus disease 2019 (COVID-19): A Review. JAMA. 2020;324(8):782-93
- 3. Rostami A, Sepidarkish M, Leeflang M, et al. SARS-CoV-2 seroprevalence worldwide: a systematic review and meta-analysis. Clin Microbiol Infect 2021;27(3):331-40.
- 4. Yalçın A. COVID-19 sürecinde yoğun bakım yönetimi. Review. Medical Research Reports. 2020;3(2):66-85.
- 5. Jiang B, Wei H. Oxygen therapy strategies and techniques to treat hypoxia in COVID-19 patients. Eur Rev Med Pharmacol Sci 2020;24(19):10239-46.
- 6. Dhont S, Derom E, Van Braeckel E, Depuydt P, Lambrecht BN. The pathophysiology of 'happy' hypoxemia in COVID-19. Respir Res 2020;21(1):198.
- 7. Mo X, Jian W, Su Z, et al. Abnormal pulmonary function in COVID-19 patients at time of hospital discharge. Eur Respir J 2020;55(6):2001217.
- 8. Endeman H, van der Zee P, van Genderen ME, van den Akker JPC, Gommers D. Progressive respiratory failure in COVID-19: a hypothesis. Lancet Infect Dis 2020;20(11):1365.
- 9. Bellan M, Soddu D, Balbo PE, et al. Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge. JAMA Netw Open 2021;4(2):e2036142.
- 10. Ekbom E, Frithiof R, Emilsson Öi, et al. Impaired diffusing capacity for carbon monoxide is common in critically ill Covid-19 patients at four months post-discharge. Respir Med 2021;182:106394.
- 11. Huang C, Huang L, Wang Y, et al. 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;397(10270):220-32.
- 12. Truffaut L, Demey L, Bruyneel AV, et al. Post-discharge critical COVID-19 lung function related to severity of radiologic lung involvement at admission. Respir Res 2021;22(1):29.
- 13. Balbi M, Conti C, Imeri G, et al. Post-discharge chest CT findings and pulmonary function tests in severe COVID-19 patients. Eur J Radiol 2021;138:109676.
- 14. Steinbeis F, Thibeault C, Doellinger F, et al. Severity of respiratory failure and computed chest tomography in acute COVID-19 correlates with pulmonary function and respiratory symptoms after infection with SARS-CoV-2: An observational longitudinal study over 12 months. Respir Med 2022;191:106709.
- 15. Sundh J, Palm A, Wahlberg J, Runold M, Ekström M. Impact of covid-19 on long-term oxygen therapy 2020: A nationwide study in Sweden. PLoS One 2022;17(4):e0266367.
- 16. Ismail J, Bansal A. Medical oxygen: A lifesaving drug during the COVID-19 pandemic-source and distribution. Indian J Pediatr 2022;89(6):607-15.
- 17. Arora A, Hasan MMF. Flexible oxygen concentrators for medical applications. Sci Rep 2021;11(1):14317.
- 18. Zorlu D. Is the use of home-type respiratory support devices effective? J DEU Med 2021;35(2):201-17.
- 19. Nowadly CD, Portillo DJ, Davis ML, Hood RL, De Lorenzo RA. The use of portable oxygen concentrators in low-resource settings: A Systematic Review. Prehosp Disaster Med 2022;37:247-54.
- 20. Kvale PA, Conway WA, Coates EO. Nocturnal Oxygen Therapy Trial Group. Continuous or Nocturnal Oxygen Therapy in Hypoxemic Chronic Obstructive Lung Disease: A Clinical Trial. Ann Intern Med 1980;93(6):391-8.
- 21. Ringbaek TJ, Viskum K, Lange P. Does long-term oxygen therapy reduce hospitalisation in hypoxaemic chronic obstructive pulmonary disease? Eur Respir J 2002;20(1):38-42.
- 22. Stuart Harris C, Bishop J, Clark TJH, et al. Medical Research Council Working Party. Long term domiciliary oxygen therapy in chronic hypoxic cor pulmonale complicating chronic bronchitis and emphysema. Report of the Medical Research Council Working Party. Lancet 1981;1(8222):681-6.
- 23. Düzenli H, Doğan ÖT, Berk S, Özşahin SL, Akkurt İ. Kronik solunum yetmezliği olan olgularda uzun süreli oksijen tedavisinin yaşam süresi üzerine etkisi. Tuberk Toraks 2008;56(2):179-86.
- 24. Guan W, Ni Z, Hu Y, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med 2020;382(18):1708-20.
- 25. Alsharif W, Qurashi A. Effectiveness of COVID-19 diagnosis and management tools: A review. Radiography (Lond) 2021;27(2):682-7.
- 26. Berlin DA, Gulick RM, Martinez FJ. Severe Covid-19. N Engl J Med 2020:17;383(25):2451-60.
- 27. Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using Open SAFELY. Nature 2020 Aug;584(7821):430-6.
- 28. Zhou F, Yu T, Du R, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet 2020;395(10229):1054-62.
- 29. Wang D, Hu B, Hu C, et al. Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China. JAMA. 2020;323(11):1061-9.
Details
| Primary Language | English |
|---|---|
| Subjects | Chest Diseases |
| Journal Section | Original Research |
| Authors | |
| Project Number | - |
| Early Pub Date | May 11, 2024 |
| Publication Date | |
| Submission Date | March 21, 2024 |
| Acceptance Date | May 1, 2024 |
| Published in Issue | Year 2024 Volume: 14 Issue: 3 |