BibTex RIS Kaynak Göster

Evaluation of Vitamin D Levels in Prediabetic Patients

Yıl 2016, Cilt: 16 Sayı: 3, 313 - 318, 23.09.2016
https://doi.org/10.17098/amj.28410

Öz

Objectives: Prediabetes is a highly risky condition for Type 2 Diabetes Mellitus (T2DM). In some of the cellular, preclinical and observational studies, it was shown that low vitamin D levels play role in the development of T2DM by affecting the synthesis and secretion of insulin. In this study, our aim was to evaluate the vitamin D levels in prediabetic patients.

Materials and methods: Forty-five prediabetic patients and 96 control subjects with an age range of 18-65 years were included to the study. Patients with other diseases were excluded. Physical examinations, arterial blood pressure measurements, and glucose and vitamin D levels were obtained after an 8 hour fasting period in our study population. Vitamin D levels were studied with high-performance liquid chromatography (HPLC).

Results: In all subjects of our study; there was a low significant inverse correlation between FPG and vitamin D levels (r=-0.332, p< 0.001). But a significant correlation wasn’t found between HbA1c and vitamin D levels. When the comparison between normoglycemic and prediabetic groups was performed, vitamin D levels were found significantly low in the prediabetic group (32.79±17.17 ng/ml vs 21.53±6.93 ng/ml, respectively).

Conclusion: Studies about the role of vitamin D deficiency in the development of prediabetes have increased in recent years. Effects of vitamin D in the prevention and management of T2DM have been shown in many studies. In the light of these studies, the factors which contribute to the development of T2DM gain more importance for the development of new treatment modalities.

Kaynakça

  • Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M. Prediabetes: a high- risk state for diabetes development. The Lancet. 2012;379(9833):2279-90.
  • Mitri J, Muraru MD, Pittas AG. Vitamin D and Type 2 Diabetes: a Systematic Review. European Journal of Clinical Nutrition 2011;65:1005–15.
  • Giorelli GDV, Matos LND, Saado A, Soibelman VL, Dias CD. No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross- sectional study. Sao Paulo Med J. 2015;133 (2):73-7.
  • Dutta D, Maisnam I, Shrivastava A, et al. Serum vitamin –D predicts insülin resistance in individuals with prediabetes. Indian J Med Res 2013;138:853-60.
  • Danescu LG. Shiri L. Levy J. Vitamin D and Diabetes Mellitus. Endocrin.2009;35:11-7.
  • Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and Diabetes. Rheum Dis Clin N Am.2012;38:179–206.
  • Griz LHM, Bandeira F, Gabbay MAL, Dib SA, EduadeCarvalho EF. Vitamin D and diabetes mellitus: an update – 2013. Arq Bras Endocrinol Metab. 2014; 58(1):1-8.
  • Krul-Poel Y.H.M, Westra S, VanWijland H.J.J, et al. Vitamin D status and health-related quality of life in patients with Type 2 diabetes. Diabet. Med. 2016;33(3):306.
  • Mezza T, Muscogiuri G, Sorice GP, et al. Vitamin D Deficiency: A New Risk Factorfor Type 2 Diabetes? Ann Nutr Metab 2012;61:337–48.
  • Teegarden D, Donkin SS. Vitamin D: emerging new roles in insülin sensitivity. Nutrition Research Reviews.2009;22;82–92.
  • Abbasi F, Blasey C, Feldman D, Caulfield MP, Hantash FM, Reaven GM. Low Circulating 25-Hydroxyvitamin D Concentrations are Associated with Defects in Insulin Action and Insulin Secretion in Persons with Prediabetes. 2015;145:714–9
  • Ozfirat Z. Chowdhury TA. Vitamin D deficiency and type 2 diabetes. Postgrad Med J 2010;86:18-25
  • Knekt P, Laaksonen M, Mattila C, et al. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology 2008;19:666–71.
  • Shankar A,Sabanayagam C, Kalıdındı S. Serum25-Hydroxyvitamin D Levels and Prediabetes Among Subjects Free of Diabetes. Diabetes Care. 2011;34:1114–19.
  • Modi K.D, Ahmed M.I, Chandwani R, Hari Kumar K.V.S. Prevalance of vitamin D deficiency across the spectrum of glucoseintolerance. Journal of Diabetes & Metabolic Disorder. 2015;14:54.
  • Davidson MB, Duran P, Lee ML, Frıedman TC, High-Dose. Vitamin D Supplementation in People with Prediabetes and Hypovitaminosis D. DiabetesCare 2013;36:260–6.
  • VonHurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insülin resistance in South Asian women living in New Zealand who are insülin resistant and vitamin D deficient – a randomised, placebo-controlled trial. British Journal of Nutrition 2010;103,549–55.
  • Seida JC, Mitri J, Colmers IN, et al. Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab, October 2014;99(10):3551–60.

Prediyabetik Hastalarda Vitamin D Düzeylerinin Değerlendirilmesi

Yıl 2016, Cilt: 16 Sayı: 3, 313 - 318, 23.09.2016
https://doi.org/10.17098/amj.28410

Öz

Amaç:  Prediyabet, tip 2 diyabetes mellitus (T2DM) için yüksek riskli durumdur. Yapılan hücresel, preklinik ve gözlemsel çalışmalar düşük D vitamin düzeyinin insülin sentez ve sekresyonunu etkileyerek T2DM gelişimindeki rolü olduğunu göstermektedir. Bu çalışma ile prediyabetik hastalarda vitamin D düzeyinin ilişkisinin gösterilmesi amaçlanmıştır.

Materyal ve Metot: 18-65 yaş arası 45 prediyabetik ve 96 kontrol grubu çalışmamıza dâhil edildi. Ek hastalıkları olan kişiler çalışma dışı bırakıldı. Çalışma grubumuzun fizik muayeneleri yapıldı, arteriyel kan basınçları ölçüldü, 8 saatlik açlığı takiben glukoz, vitamin D düzeylerine bakıldı. Vitamin D düzeyi high-performance liquid chromatography (HPLC) yöntemi ile çalışıldı.

Bulgular: Çalışmamıza katılan tüm bireylerde vitamin D düzeyleri ile açlık kan şekeri (AKŞ) arasında düşük düzeyde anlamlı ters yönlü korelasyon gözlendi (r=-0,332, p< 0,001). HbA1c ile vitamin D arasında ise korelasyon izlenmedi (r=-0,191, p=0,055). Normoglisemik ve prediyabetik hastaların vitamin D düzeyleri karşılaştırıldığında, prediyabetik grupta vitamin D düzeyleri anlamlı olarak düşük bulundu (sırasıyla; 32,79±17,17 ng/ml ve 21,53±6,93 ng/ml).

Sonuç: Son yıllarda vitamin D eksikliği ya da yetersizliğinin prediyabet gelişimi rolü olabileceği yönünde çalışmalar giderek artmaktadır. Diyabeti önlemede ve tedavisinde vitamin D’nin etkisi çeşitli çalışmalarla gösterilmektedir. Bu çalışmalar doğrultusunda diyabet gelişimine katkısı olan etkenler, yeni tedavi modelleri gelişimi açısından daha da önem kazanmaktadır. 

Kaynakça

  • Tabak AG, Herder C, Rathmann W, Brunner EJ, Kivimaki M. Prediabetes: a high- risk state for diabetes development. The Lancet. 2012;379(9833):2279-90.
  • Mitri J, Muraru MD, Pittas AG. Vitamin D and Type 2 Diabetes: a Systematic Review. European Journal of Clinical Nutrition 2011;65:1005–15.
  • Giorelli GDV, Matos LND, Saado A, Soibelman VL, Dias CD. No association between 25-hydroxyvitamin D levels and prediabetes in Brazilian patients. A cross- sectional study. Sao Paulo Med J. 2015;133 (2):73-7.
  • Dutta D, Maisnam I, Shrivastava A, et al. Serum vitamin –D predicts insülin resistance in individuals with prediabetes. Indian J Med Res 2013;138:853-60.
  • Danescu LG. Shiri L. Levy J. Vitamin D and Diabetes Mellitus. Endocrin.2009;35:11-7.
  • Takiishi T, Gysemans C, Bouillon R, Mathieu C. Vitamin D and Diabetes. Rheum Dis Clin N Am.2012;38:179–206.
  • Griz LHM, Bandeira F, Gabbay MAL, Dib SA, EduadeCarvalho EF. Vitamin D and diabetes mellitus: an update – 2013. Arq Bras Endocrinol Metab. 2014; 58(1):1-8.
  • Krul-Poel Y.H.M, Westra S, VanWijland H.J.J, et al. Vitamin D status and health-related quality of life in patients with Type 2 diabetes. Diabet. Med. 2016;33(3):306.
  • Mezza T, Muscogiuri G, Sorice GP, et al. Vitamin D Deficiency: A New Risk Factorfor Type 2 Diabetes? Ann Nutr Metab 2012;61:337–48.
  • Teegarden D, Donkin SS. Vitamin D: emerging new roles in insülin sensitivity. Nutrition Research Reviews.2009;22;82–92.
  • Abbasi F, Blasey C, Feldman D, Caulfield MP, Hantash FM, Reaven GM. Low Circulating 25-Hydroxyvitamin D Concentrations are Associated with Defects in Insulin Action and Insulin Secretion in Persons with Prediabetes. 2015;145:714–9
  • Ozfirat Z. Chowdhury TA. Vitamin D deficiency and type 2 diabetes. Postgrad Med J 2010;86:18-25
  • Knekt P, Laaksonen M, Mattila C, et al. Serum Vitamin D and Subsequent Occurrence of Type 2 Diabetes. Epidemiology 2008;19:666–71.
  • Shankar A,Sabanayagam C, Kalıdındı S. Serum25-Hydroxyvitamin D Levels and Prediabetes Among Subjects Free of Diabetes. Diabetes Care. 2011;34:1114–19.
  • Modi K.D, Ahmed M.I, Chandwani R, Hari Kumar K.V.S. Prevalance of vitamin D deficiency across the spectrum of glucoseintolerance. Journal of Diabetes & Metabolic Disorder. 2015;14:54.
  • Davidson MB, Duran P, Lee ML, Frıedman TC, High-Dose. Vitamin D Supplementation in People with Prediabetes and Hypovitaminosis D. DiabetesCare 2013;36:260–6.
  • VonHurst PR, Stonehouse W, Coad J. Vitamin D supplementation reduces insülin resistance in South Asian women living in New Zealand who are insülin resistant and vitamin D deficient – a randomised, placebo-controlled trial. British Journal of Nutrition 2010;103,549–55.
  • Seida JC, Mitri J, Colmers IN, et al. Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab, October 2014;99(10):3551–60.
Toplam 18 adet kaynakça vardır.

Ayrıntılar

Bölüm Araştırmalar
Yazarlar

Ahmet Keskin

Yayımlanma Tarihi 23 Eylül 2016
Yayımlandığı Sayı Yıl 2016 Cilt: 16 Sayı: 3

Kaynak Göster

APA Keskin, A. (2016). Evaluation of Vitamin D Levels in Prediabetic Patients. Ankara Medical Journal, 16(3), 313-318. https://doi.org/10.17098/amj.28410
AMA Keskin A. Evaluation of Vitamin D Levels in Prediabetic Patients. Ankara Med J. Eylül 2016;16(3):313-318. doi:10.17098/amj.28410
Chicago Keskin, Ahmet. “Evaluation of Vitamin D Levels in Prediabetic Patients”. Ankara Medical Journal 16, sy. 3 (Eylül 2016): 313-18. https://doi.org/10.17098/amj.28410.
EndNote Keskin A (01 Eylül 2016) Evaluation of Vitamin D Levels in Prediabetic Patients. Ankara Medical Journal 16 3 313–318.
IEEE A. Keskin, “Evaluation of Vitamin D Levels in Prediabetic Patients”, Ankara Med J, c. 16, sy. 3, ss. 313–318, 2016, doi: 10.17098/amj.28410.
ISNAD Keskin, Ahmet. “Evaluation of Vitamin D Levels in Prediabetic Patients”. Ankara Medical Journal 16/3 (Eylül 2016), 313-318. https://doi.org/10.17098/amj.28410.
JAMA Keskin A. Evaluation of Vitamin D Levels in Prediabetic Patients. Ankara Med J. 2016;16:313–318.
MLA Keskin, Ahmet. “Evaluation of Vitamin D Levels in Prediabetic Patients”. Ankara Medical Journal, c. 16, sy. 3, 2016, ss. 313-8, doi:10.17098/amj.28410.
Vancouver Keskin A. Evaluation of Vitamin D Levels in Prediabetic Patients. Ankara Med J. 2016;16(3):313-8.