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Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine

Yıl 2018, Cilt: 31 Sayı: 2, 408 - 414, 01.06.2018

Elvan Hasanoğlu Özkan Hamit Emre Kızıl İffet Şakıyan Dilek Nartop Nurşen Sarı Güleray Ağar

Öz



The purpose of the research
was to evaluate the genotoxic and anti-genotoxic properties of Schiff bases and their Mn (III) complexes containing
L-aspartic acid, and L-phenylalanine. The
anti-genotoxic properties of four compounds in human lymphocytes cells were
investigated by sister chromatid exchanges (SCEs) test system against aflatoxin
B1 (AFB1). The results showed that compounds
have strong anti-genotoxic properties.



 

Anahtar Kelimeler

Aflatoxin Bı Mn(III) complexes mutagenicity

Kaynakça

  • [1] Willison, E.O.C., Larissa, B. R., Antônio, P. N., Ricardo, A. M., Arthur, A. V.,“Extended validation of a senstive and robust method for simultaneous quantification of aflatoxins B1, B2, G1 and G2 in Brazil nuts by HPLC-FLD”, Journal of Food Composition and Analysis, 60: 90-96 (2017).
  • [2] Joo, M., Baek, S.H., Cheon, S.A., Chun, H.S., Choi, S.W., Park, T. J., “Development of aflatoxin B1 aptasensor based on wide-range fluorescence detection using graphene oxide quencher”, Colloids and Surfaces B: Biointerfaces, 154: 27–32 (2017).
  • [3] Yao, M., Wang, L., Fang, C., “The chemiluminescence immunoassay for aflatoxin B1 based on functionalized magnetic nanoparticles with two strategies of antigen probe immobilization”, Luminescence, 32: 661-665 (2017).
  • [4] Anar, M., Hasanoğlu Özkan, E., Öğütçü, H., Ağar, G., Şakıyan, I., Sarı, N., “Useful agents against aflatoxin B1–antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine”, Artificial Cells, Nanomedicine, and Biotechnology: An International Journal, 44: 853-858 (2016).
  • [5] Şakıyan, I., Anar, M., Öğütçü, H., Ağar, G., Sarı, N., “Schiff bases attached L-glutamine and L-asparagine: First investigation on antimutagenic and antimicrobial analyses”, Artificial Cells, Nanomedicine, and Biotechnology: An International Journal, 42: 199-204 (2014).
  • [6] Sakiyan, I., “Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiff bases”, Transition Metal Chemistry, 32: 131–135 (2007).
  • [7] Sakiyan, I., Gunduz, N., Gunduz, T., “Synthesis and characterization of manganese (III) complexes of Schiff bases derived from amino acids and 2-hydroxy-1-naphthaldehyde”, Synth React Inorg Met-Org Chem, 31: 1175–1187 (2001).
  • [8] Ceker S., Agar G., Alpsoy L., Nardemir G., Kizil H. E. Antagonistic effects of Satureja hortensis essential oil against AFB1 on human lymphocytes in vitro. Methods, 48, 65-71, (2014).
  • [9] Sakıyan, I., Ozcan, Y., Ide, S.,”[N-(2-Hidroksi-1-Naftaliden)Histidin] Schiff bazının sentezi ve kristal yapı analizi”, C. B. U . J. Sci., 2, 99 (2006).
  • [10] Nakamoto, K., “Infrared and Raman Spectra of Inorganic and Coordination Compounds”, Illinois, Chicago, 99-105 (1962).
  • [11] Roy, M. K., Kuwabara, Y., Hara, K., Watanabe, Y., Tamai, Y., “Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N ’-nitro-N-nitrosoguanidine (MNNG)”, Biosci Biotech Biochem, 66: 1400-1402 (2002).
  • [12] Tavares, D.C., Cecchi, A.O., Antunes, L. M., Takahash, C.S., “Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells”, Teratog Carcinog Mutagen, 18: 153-161 (1998).
  • [13] Handique, A. K., Aprem, H., “Antimutagenic activity of tryptophan and alanine”, Curr Sci., 72: 578-580 (1997).

Yıl 2018, Cilt: 31 Sayı: 2, 408 - 414, 01.06.2018

Elvan Hasanoğlu Özkan Hamit Emre Kızıl İffet Şakıyan Dilek Nartop Nurşen Sarı Güleray Ağar

Öz

Kaynakça

  • [1] Willison, E.O.C., Larissa, B. R., Antônio, P. N., Ricardo, A. M., Arthur, A. V.,“Extended validation of a senstive and robust method for simultaneous quantification of aflatoxins B1, B2, G1 and G2 in Brazil nuts by HPLC-FLD”, Journal of Food Composition and Analysis, 60: 90-96 (2017).
  • [2] Joo, M., Baek, S.H., Cheon, S.A., Chun, H.S., Choi, S.W., Park, T. J., “Development of aflatoxin B1 aptasensor based on wide-range fluorescence detection using graphene oxide quencher”, Colloids and Surfaces B: Biointerfaces, 154: 27–32 (2017).
  • [3] Yao, M., Wang, L., Fang, C., “The chemiluminescence immunoassay for aflatoxin B1 based on functionalized magnetic nanoparticles with two strategies of antigen probe immobilization”, Luminescence, 32: 661-665 (2017).
  • [4] Anar, M., Hasanoğlu Özkan, E., Öğütçü, H., Ağar, G., Şakıyan, I., Sarı, N., “Useful agents against aflatoxin B1–antibacterial azomethine and Mn(III) complexes involving L-Threonine, L-Serine, and L-Tyrosine”, Artificial Cells, Nanomedicine, and Biotechnology: An International Journal, 44: 853-858 (2016).
  • [5] Şakıyan, I., Anar, M., Öğütçü, H., Ağar, G., Sarı, N., “Schiff bases attached L-glutamine and L-asparagine: First investigation on antimutagenic and antimicrobial analyses”, Artificial Cells, Nanomedicine, and Biotechnology: An International Journal, 42: 199-204 (2014).
  • [6] Sakiyan, I., “Synthesis and characterization of four new manganese(III) complexes and amino acid (L-aspartic acid, L-asparagine, L-glutamic acid, L-glutamine) Schiff bases”, Transition Metal Chemistry, 32: 131–135 (2007).
  • [7] Sakiyan, I., Gunduz, N., Gunduz, T., “Synthesis and characterization of manganese (III) complexes of Schiff bases derived from amino acids and 2-hydroxy-1-naphthaldehyde”, Synth React Inorg Met-Org Chem, 31: 1175–1187 (2001).
  • [8] Ceker S., Agar G., Alpsoy L., Nardemir G., Kizil H. E. Antagonistic effects of Satureja hortensis essential oil against AFB1 on human lymphocytes in vitro. Methods, 48, 65-71, (2014).
  • [9] Sakıyan, I., Ozcan, Y., Ide, S.,”[N-(2-Hidroksi-1-Naftaliden)Histidin] Schiff bazının sentezi ve kristal yapı analizi”, C. B. U . J. Sci., 2, 99 (2006).
  • [10] Nakamoto, K., “Infrared and Raman Spectra of Inorganic and Coordination Compounds”, Illinois, Chicago, 99-105 (1962).
  • [11] Roy, M. K., Kuwabara, Y., Hara, K., Watanabe, Y., Tamai, Y., “Antimutagenic effect of amino acids on the mutagenicity of N-methyl-N ’-nitro-N-nitrosoguanidine (MNNG)”, Biosci Biotech Biochem, 66: 1400-1402 (2002).
  • [12] Tavares, D.C., Cecchi, A.O., Antunes, L. M., Takahash, C.S., “Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells”, Teratog Carcinog Mutagen, 18: 153-161 (1998).
  • [13] Handique, A. K., Aprem, H., “Antimutagenic activity of tryptophan and alanine”, Curr Sci., 72: 578-580 (1997).
Toplam 13 adet kaynakça vardır.

Ayrıntılar

Bölüm Chemistry
Yazarlar

Elvan Hasanoğlu Özkan

Hamit Emre Kızıl Bu kişi benim

İffet Şakıyan Bu kişi benim

Dilek Nartop

Nurşen Sarı

Güleray Ağar

Yayımlanma Tarihi 1 Haziran 2018
Yayımlandığı Sayı Yıl 2018 Cilt: 31 Sayı: 2

Kaynak Göster

APA Hasanoğlu Özkan, E., Kızıl, H. E., Şakıyan, İ., Nartop, D., vd. (2018). Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine. Gazi University Journal of Science, 31(2), 408-414.
AMA Hasanoğlu Özkan E, Kızıl HE, Şakıyan İ, Nartop D, Sarı N, Ağar G. Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine. Gazi University Journal of Science. Haziran 2018;31(2):408-414.
Chicago Hasanoğlu Özkan, Elvan, Hamit Emre Kızıl, İffet Şakıyan, Dilek Nartop, Nurşen Sarı, ve Güleray Ağar. “Anti-Genotoxic Effects of Schiff Bases and Their Mn(III) Complexes Containing L-Aspartic Acid and L-Phenylalanine”. Gazi University Journal of Science 31, sy. 2 (Haziran 2018): 408-14.
EndNote Hasanoğlu Özkan E, Kızıl HE, Şakıyan İ, Nartop D, Sarı N, Ağar G (01 Haziran 2018) Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine. Gazi University Journal of Science 31 2 408–414.
IEEE E. Hasanoğlu Özkan, H. E. Kızıl, İ. Şakıyan, D. Nartop, N. Sarı, ve G. Ağar, “Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine”, Gazi University Journal of Science, c. 31, sy. 2, ss. 408–414, 2018.
ISNAD Hasanoğlu Özkan, Elvan vd. “Anti-Genotoxic Effects of Schiff Bases and Their Mn(III) Complexes Containing L-Aspartic Acid and L-Phenylalanine”. Gazi University Journal of Science 31/2 (Haziran 2018), 408-414.
JAMA Hasanoğlu Özkan E, Kızıl HE, Şakıyan İ, Nartop D, Sarı N, Ağar G. Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine. Gazi University Journal of Science. 2018;31:408–414.
MLA Hasanoğlu Özkan, Elvan vd. “Anti-Genotoxic Effects of Schiff Bases and Their Mn(III) Complexes Containing L-Aspartic Acid and L-Phenylalanine”. Gazi University Journal of Science, c. 31, sy. 2, 2018, ss. 408-14.
Vancouver Hasanoğlu Özkan E, Kızıl HE, Şakıyan İ, Nartop D, Sarı N, Ağar G. Anti-genotoxic Effects of Schiff bases and their Mn(III) Complexes Containing L-Aspartic acid and L-Phenylalanine. Gazi University Journal of Science. 2018;31(2):408-14.