ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME

Ecenur Bayır; Gözde Elgin Cebe

doi:10.33483/jfpau.1393243

Derleme

ENFLAMMATORY BOWEL DISEASES AND MEDICINAL PLANTS: A CURRENT REVIEW

Yıl 2024, Cilt: 48 Sayı: 2, 642 - 657

Ecenur Bayır Gözde Elgin Cebe

https://doi.org/10.33483/jfpau.1393243

Öz

Objective: Enflammatory bowel disease (EBD) is a chronic enflammation of the gastrointestinal tract (GIS) that consists of episodes of attacks and remissions characterized by ulceration, bleeding, fluid and electrolyte loss. Ulcerative colitis and Chron, are the major clinical forms of EBD, the etiology and pathogenesis of which are unclear. EBD, the incidence and prevalence of which has been increasing in our country and in the world in recent years, negatively affects the quality of life of people. This makes the treatment of the disease even more important. However, these treatment methods may be insufficient for prolonging the remission period of the disease and preventing its progression. For this reason, patients tend to seek different complementary therapies in addition to their medical treatments. Among these methods, the most frequently applied complementary therapy is herbal products.
Result and Discussion: The use of herbal products can have positive effects on the disease as well as cause negative effects. For this reason, products with certain standards should be used in the appropriate disease, in the appropriate form, in the appropriate dose and under the control of the doctor / pharmacist. When the studies in the literature are evaluated; Despite the abundance of medicinal herbs used in anxiety and sleep disordersenflammatory bowel disease, the potential mechanism of action and positive/negative effects of many of them have not been fully revealed. Since the wrong and unconscious irrational use of these herbs may lead to worsening of the course of the disease, more researches are needed to examine examine medicinal herbs used in enflammatory bowel disease.

Anahtar Kelimeler

Chrons disease, enflammatory bowel disease, medicinal herbs, ulcerative colitis

Kaynakça

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ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME

Yıl 2024, Cilt: 48 Sayı: 2, 642 - 657

Ecenur Bayır Gözde Elgin Cebe

https://doi.org/10.33483/jfpau.1393243

Öz

Amaç: Enflamatuar bağırsak hastalığı (EBH), ülserasyon, kanama, sıvı ve elektrolit kaybı ile karakterize, atak ve remisyon dönemlerinden oluşan gastrointestinal sistemin (GİS) kronik enflamasyonudur. Ülseratif kolit ve Chron, etiyolojisi ve patogenezi tam olarak belli olmayan EBH’nin majör klinik formlarıdır. Son yıllarda ülkemizde ve dünyada insidansı ve prevalansı gittikçe artan EBH, bireylerin yaşam kalitesini olumsuz etkilemektedir. Bu durum hastalığın tedavisini daha da önemli hale getirmektedir. Fakat bu tedavi yöntemleri hastalığın remisyon süresinin uzatılması ve progresyonunun önlenmesi için yetersiz kalabilmektedir. Bu nedenle hastalar esas tedavilerine ek olarak farklı tamamlayıcı tedavi arayışlarına yönelmektedir. Bu yöntemler arasında hastaların en sık başvurduğu tamamlayıcı tedavi, bitkisel ürünlerdir.
Sonuç ve Tartışma: Bitkisel ürünlerin kullanımı, hastalık üzerinde olumlu etkiler yapabildiği gibi olumsuz etkilere de yol açabilmektedir. Bu nedenle belli standartlara sahip ürünlerin uygun hastalıkta, uygun formda, uygun dozda ve hekim/eczacı kontrolünde kullanılması gerekmektedir. Literatürdeki çalışmalar değerlendirildiğinde; enflamatuar bağırsak hastalıklarında kullanılan tıbbi bitkilerin fazlalığına rağmen birçoğunun potansiyel etki mekanizmasının ve olumlu/olumsuz etkilerinin tam olarak ortaya konmadığı görülmektedir. Bu bitkilerin yanlış ve bilinçsizce kullanımı hastalığın seyrinin kötüleşmesine yol açabileceğinden enflamatuar bağırsak hastalıklarında kullanılan tıbbi bitkilerle ilgili daha fazla araştırmaya ihtiyaç duyulmaktadır.

Anahtar Kelimeler

Chron hastalığı, enflamatuar bağırsak hastalığı, tıbbi bitkiler, ülseratif kolit

Kaynakça

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78. Shayesteh, F., Haidari, F., Shayesteh, A.A., Mohammadi-Asl, J., Ahmadi-Angali, K. (2020). Ginger in patients with active ulcerative colitis: A study protocol for a randomized controlled trial. Trials, 21, 278. [CrossRef]
79. Ballester, P., Cerdá, B., Arcusa, R., Marhuenda, J., Yamedjeu, K., Zafrilla, P. (2022). Effect of Ginger on inflammatory diseases. Molecules, 27(21), 7223. [CrossRef]
80. Fuloria, S., Mehta, J., Chandel, A., Sekar, M., Rani, N.N.I.M., Begum, M.Y., Subramaniyan, V., Chidambaram, K., Thangavelu, L., Nordin, R., Wu, Y.S., Sathasivam, K.V., Lum, P.T., Meenakshi, D.U., Kumarasamy, V., Azad, A.K., Fuloria, N.K. (2022). A comprehensive review on the therapeutic potential of Curcuma longa Linn. in relation to its major active constituent Curcumin. Frontiers in Pharmacology, 13, 820806. [CrossRef]
81. Lima, A.M., Nascimento, C.E.C., Santos, C.H.M.D., Dourado, D.M., Siqueira, G.E.C., Rigo, G.M., Bernardi, L.U., Leonel, P.O.S., Matias, R., Ferreira, V.C., Souza, V.C.R.P. (2019). Effıcacy of Curcuma longa in the treatment of diversion colitis in rats. Arquivos Brasileiros de Cirurgia Digestiva, 32(3), e1456. [CrossRef]
82. Yuandani Jantan, I., Rohani, A.S., Sumantri, I.B. (2021). Immunomodulatory effects and mechanisms of curcuma species and their bioactive compounds: A review. Frontiers in Pharmacology, 12, 643119. [CrossRef]
83. Hagenlocher, Y., Satzinger, S., Civelek, M., Feilhauer, K., Köninger, J., Bischoff, S.C., Lorentz, A. (2017). Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis. Molecular Nutrition & Food Research, 61(9). [CrossRef]
84. Lonati, E., Sala, G., Corbetta, P., Pagliari, S., Cazzaniga, E., Botto, L., Rovellini, P., Bruni, I., Palestini, P., Bulbarelli, A. (2023). Digested Cinnamon (Cinnamomum verum J. Presl) bark extract modulates claudin-2 gene expression and protein levels under TNFα/IL-1β inflammatory stimulus. International Journal of Molecular Sciences, 24(11), 9201. [CrossRef]
85. Hagenlocher, Y., Hösel, A., Bischoff, S.C., Lorentz, A. (2016). Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10(-/-) colitis. The Journal of Nutritonal Biochemistry, 30, 85-92. [CrossRef]
86. Catanzaro, D., Rancan, S., Orso, G., Dall'Acqua, S., Brun, P., Giron, M.C., Carrara, M., Castagliuolo, I., Ragazzi, E., Caparrotta, L., Montopoli, M. (2015). Boswellia serrata preserves intestinal epithelial barrier from oxidative and inflammatory damage. PLoS One, 10(5), e0125375.
87. Elnawasany, S. (2023). Boswellia carries hope for patients with inflammatory bowel disease (IBD). Medicinal plants-chemical, biochemical, and pharmacological approache. IntechOpen, 2023. [CrossRef]
88. Holtmeier, W., Zeuzem, S., Preiβ, J., Kruis, W., Böhm, S., Maaser, C., Raedler, A., Schmidt, C., Schnitker, J., Schwarz, J., Zeitz, M., Caspary, W. (2011). Randomized, placebo-controlled, double-blind trial of Boswellia serrata in maintaining remission of Crohn's disease: Good safety profile but lack of efficacy, Inflammatory Bowel Diseases, 17(2), 573-582. [CrossRef]
89. Nowak, W., Jeziorek, M. (2023). The role of Flaxseed in improving human health. Healthcare, 11(3), 395.
90. Morshedzadeh, N., Shahrokh, S., Aghdaei, H.A., Amin Pourhoseingholi, M., Chaleshi, V., Hekmatdoost, A., Karimi, S., Zali, M.R., Mirmiran, P. (2019). Effects of flaxseed and flaxseed oil supplement on serum levels of inflammatory markers, metabolic parameters and severity of disease in patients with ulcerative colitis. Complementary Therapies in Medicine, 46, 36-43. [CrossRef]
91. Palla, A.H., Gilani, A.U., Bashir, S., Ur Rehman, N. (2020). Multiple mechanisms of Flaxseed: Effectiveness in inflammatory bowel disease. Evidence Based Complement Alternative Medicine, 2020, 7974835. [CrossRef]
92. Zhou, Q., Ma, L., Zhao, W., Zhao, W., Han, X., Niu, J., Li, R., Zhao, C. (2020). Flaxsed oil alleviates dextran sulphate sodium-induced ulcerative colitis in rats. Journal of Functional Foods, 64, 103602. [CrossRef]
93. Zugaro, S., Benedetti, E., Caioni, G. (2023). Garlic (Allium sativum L.) as an ally in the treatment of inflammatory bowel diseases. Current Issues in Molecular Biology, 45(1), 685-698. [CrossRef]
94. Recinella, L., Gorica, E., Chiavaroli, A., Fraschetti, C., Filippi, A., Cesa, S., Cairone, F., Martelli, A., Calderone, V., Veschi, S., Lanuti, P., Cama, A., Orlando, G., Ferrante, C., Menghini, L., Di Simone, S.C., Acquaviva, A., Libero, M.L., Nilofar, Brunetti, L. (2022). Anti-inflammatory and antioxidant effects induced by Allium sativum L. extracts on an ex vivo experimental model of ulcerative colitis. Foods, 11(22), 3559. [CrossRef]
95. Boakye, Y.D., Mensah, D.O., Agyei, E.K., Agyen, R., Adjei, D.K., Agyare, C. (2022). Health benefits of Garlic (Allium sativum) in gastrointestinal disorders. Goyal, M.R., Birwal, P., Chauhan, N. (Eds.), Herbs, spices and medicinal plants for human gastrointestinal disorders, 1st Edition, Apple Academic Press, (pp. 5-15). New York.

Toplam 95 adet kaynakça vardır.

Ayrıntılar

Birincil Dil	Türkçe
Konular	Farmasotik Botanik
Bölüm	Derleme
Yazarlar	Ecenur Bayır 0000-0003-4480-4417 Gözde Elgin Cebe 0000-0002-7253-3864
Erken Görünüm Tarihi	18 Şubat 2024
Yayımlanma Tarihi
Gönderilme Tarihi	24 Kasım 2023
Kabul Tarihi	23 Ocak 2024
Yayımlandığı Sayı	Yıl 2024 Cilt: 48 Sayı: 2

Kaynak Göster

APA	Bayır, E., & Elgin Cebe, G. (2024). ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME. Journal of Faculty of Pharmacy of Ankara University, 48(2), 642-657. https://doi.org/10.33483/jfpau.1393243
AMA	Bayır E, Elgin Cebe G. ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME. Ankara Ecz. Fak. Derg. Şubat 2024;48(2):642-657. doi:10.33483/jfpau.1393243
Chicago	Bayır, Ecenur, ve Gözde Elgin Cebe. “ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME”. Journal of Faculty of Pharmacy of Ankara University 48, sy. 2 (Şubat 2024): 642-57. https://doi.org/10.33483/jfpau.1393243.
EndNote	Bayır E, Elgin Cebe G (01 Şubat 2024) ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME. Journal of Faculty of Pharmacy of Ankara University 48 2 642–657.
IEEE	E. Bayır ve G. Elgin Cebe, “ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME”, Ankara Ecz. Fak. Derg., c. 48, sy. 2, ss. 642–657, 2024, doi: 10.33483/jfpau.1393243.
ISNAD	Bayır, Ecenur - Elgin Cebe, Gözde. “ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME”. Journal of Faculty of Pharmacy of Ankara University 48/2 (Şubat 2024), 642-657. https://doi.org/10.33483/jfpau.1393243.
JAMA	Bayır E, Elgin Cebe G. ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME. Ankara Ecz. Fak. Derg. 2024;48:642–657.
MLA	Bayır, Ecenur ve Gözde Elgin Cebe. “ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME”. Journal of Faculty of Pharmacy of Ankara University, c. 48, sy. 2, 2024, ss. 642-57, doi:10.33483/jfpau.1393243.
Vancouver	Bayır E, Elgin Cebe G. ENFLAMATUAR BAĞIRSAK HASTALIĞI VE TIBBİ BİTKİLER: GÜNCEL BİR GÖZDEN GEÇİRME. Ankara Ecz. Fak. Derg. 2024;48(2):642-57.

Kapak Resmi İndir

Makale Dosyaları

Tam Metin

Kapsam ve Amaç

Ankara Üniversitesi Eczacılık Fakültesi Dergisi, açık erişim, hakemli bir dergi olup Türkçe veya İngilizce olarak farmasötik bilimler alanındaki önemli gelişmeleri içeren orijinal araştırmalar, derlemeler ve kısa bildiriler için uluslararası bir yayım ortamıdır. Bilimsel toplantılarda sunulan bildiriler supleman özel sayısı olarak dergide yayımlanabilir. Ayrıca, tüm farmasötik alandaki gelecek ve önceki ulusal ve uluslararası bilimsel toplantılar ile sosyal aktiviteleri içerir.