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The role of pesticides in the etiology of lymphoma: A systematic review

Yıl 2020, Cilt: 12 Sayı: 2, 142 - 150, 01.06.2020
https://doi.org/10.21601/ortadogutipdergisi.639830

Öz

Aim: It is known that non-Hodgkin lymphoma risk increases in agricultural workers and it is thought that pesticides have an effect on this increase. The aim of this systematic review is to evaluate the role and effect of pesticides in the etiology of lymphoma.
Material and Methods: This systematic review was conducted in accordance with the Centre for Reviews and Dissemination 2009 guide developed by York University National Institute of Health Research. It was carried out in the databases Science Direct, EBSCO (CINAHL Complete), PUBMED, Wiley Interscience, Springer Link databases to cover the years 2014-2019.
Results: As a result of the review, six studies were included in the research and presented in “year of study, research type and sample characteristics, measurement tools used, results obtained, and level of evidence”.
Conclusion: It was found that pesticide use was associated with the risk of non-Hodgkin lymphoma and its subtypes. Occupational exposures should be assessed in communities whose main livelihood is agriculture and this group should be trained by health professionals on the use of personal protective equipment and protective behaviors.

Kaynakça

  • https://acikders.ankara.edu.tr/pluginfile.php/62780/mod_resource/content/0/4.pdf (Accessed September 26, 2019).
  • Blair A, Dosemeci M, Heineman EF. Cancer and other causes of death among male and female farmers from twenty-three states. Am J Ind Med 1993; 23(5): 729-42.
  • Blair A, Zahm SH. Agricultural exposures and cancer. Environ Health Perspect 1995; 103(8 Suppl): 205-8.
  • Keller-Byrne JE, Khuder SA, Schaub EA, McAfee O. Ameta-analysis of non-Hodgkin’s lymphoma among farmers in the central United States. Am J Ind Med 1997; 31(4): 442-4.
  • Khuder SA, Schaub EA, Keller-Byrne JE. Meta-analyses of non-Hodgkin’s lymphoma and farming. Scand J Work Environ Health 1998; 24(2): 255-61.
  • Schinasi LH, De Roos AJ, Ray RM, et al. insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women’s Health Initiative observational study cohort. Annals of Epidemiology 2015; 25: 803-10.
  • Guyton KZ, Loomis D, Grosse Y, et al. Carcinogenicity of pentachlorophenol and some related compounds. Lancet Oncol 2016; 17: 1637-8.
  • Loomis D, Guyton K, Grosse Y, et al. Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. Lancet Oncol 2015; 16: 891-2.
  • Engel LS, Laden F, Andersen A, et al. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin’s lymphoma: a report from three cohorts. Cancer Res 2007; 67: 5545-52.
  • De Roos AJ, Hartge P, Lubin JH, et al. Persistent organochlorine chemicals in plasma and risk of non-Hodgkin’s lymphoma. Cancer Res 2005; 65: 11214-26.
  • Colt JS, Rothman N, Severson RK, et al. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Blood 2009; 113: 1899-905.
  • Freeman MD, Kohles SS. Plasma levels of polychlorinated biphenyls, non-Hodgl,n lymphoma, and causation. J Environ Public Health 2012: 258981.
  • Laden F, Bertrand KA, Altshol L, Aster JC, Korrick SA, Sagiy SK. Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses’ Health Study. Cancer Epidemiol Biomark Prev 2010; 19: 1381-4.
  • Cocco P, Brennan P, Ibba A, et al. Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes. Occup Environ Med 2008; 65: 132-40.
  • Zani C, Ceretti E, Covolo L, Donato F. Do polychlorinated biphenyl cause cancer? A systematic review and meta-analysis of epidemiological studies on risk of cutaneous melanoma and non-Hodgkin lymphoma. Chemosphere 2017; 183: 97-106.
  • Blair A, Ritz B, Wesseling C, Freeman LB. Pesticides and human health. Occup Environ Med 2015; 72: 81-2.
  • Koutros S, Beane Freeman LE, Lubin JH, et al. Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study. Am J Epidemiol 2013; 177: 59-74.
  • International Agency for Research on Cancer (IARC). Malathion. 112 IARC, Lyon, France. 2015. https://www.iarc.fr/wp-content/uploads/2018/07/Mono graphVolume112-1.pdf (Accessed September 27, 2019).
  • Alavanja MC, Hofmann JN, Lynch CF, et al. Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study. PLoS One 2014; 9: e109332.
  • Bonner MR, Williams BA, Rusiecki JA, et al. Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study. Cancer Causes Control 2010; 21: 871-7.
  • Fineout-Overholt E, Melnyk BM, Stillwell SB, Williamson KM. Evidence-based practice step by step: critical appraisal of the evidence: part I. Am J Nurs 2010; 110(7): 47-52.
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151(4): 264-9.
  • Ferri MA, Specchia G, Mazza P, et al. risk of lymphoma subtypes by occupational exposure in Southern Italy. J Occup Med Toxicol 2017; 12(31): 1-10.
  • Koutros S, Harris SA, Spinelli JJ, et al. Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the North American pooled project. Environ Int 2019; 127: 199-205.
  • Bassig BA, Shu XO, Sjödin A, et al. Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. Int J Cancer 2019: 1-11.
  • Klil-Drori AJ, Kleinstern G, Seir RA, et al. Serum organochlorines and non-Hodgkin lymphoma: a case control study in Israeli Jews and Palestinians. Chemosphere 2018; 213: 395-402.
  • Purdue MP, Hoppin JA, Blair A, Dosemeci M, Alavanja MCR. Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. Int J Cancer 2007; 120(3): 642-9.
  • Environmental Protection Agency (EPA). DDT-A Brief History and Status. 2012. http://www.epa.gov/pestici des/factsheets/chemicals/ddt-brief-history-status.htm (Accessed October 1, 2019).
  • Stockholm Convention Report. Report of the conference of the Parties of the Stockholm Convention on Persistent Organic Pollutants on the work of its 4th meeting. Fourth Meeting, Geneva, 2009. http://chm.pops.int/Portals/0/ Repository/COP4/UNEP-POPS-COP.4-38.English.pdf (Accessed September 25, 2019).
  • National Pesticide Information Center (NPIC). Chemicals Evaluated for Carcinogenic Potential, Office of Pesticide Programs. U.S. Environmental Protection Agency. 2012. http://npic.orst.edu/chemicals_evaluated.pdf (Accessed September 29, 2019).
  • Environmental Protection Agency (EPA). Re-registration Eligibility Decision for Terbufos. 2006. http://www.epa. gov/pesticides/reregistration/REDs/terbufos_red.pdf (Accessed October 2, 2019).
  • Cantor KP, Blair A, Everett G, et al. Pesticides and other agricultural risk factors for non-Hodgkin’s lymphoma among men in Iowa and Minnesota. Cancer Res 1992; 52: 2447-55.
  • Waddell BL, Zahm SH, Baris D, et al. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin’s lymphoma among male farmers (United States). Cancer Causes Control 2001; 12: 509-17.
  • McDuffie HH, Pahwa P, McLaughlin JR, et al. Non-Hodgkin’s lymphoma and specific pesticide exposures in men: cross-Canada study of pesticides and health. Cancer Epidemiol Biomark Prev 2001; 10: 1155-63.
  • National Toxicological Program. Captafol. Rep Carcinog 2011; 12: 83-6.
  • Park SK, Kang D, Beane-Freeman L, et al. Cancer incidence among Paraquat exposed pesticide applicators in the agricultural health study. Int J Occup Environ Health 2009; 15(3): 274-81.
  • Rudyk C, Litteljohn D, Syed S, Dwyer Z, Hayley S. Paraquat and psychological stressor interactions as pertains to Parkinsonian co-morbidity. Neurobiol Stress 2015; 2: 85-93.
  • Blair A, Cantor KP, Zahm SH. Non-Hodgkin’s lymphoma and agricultural use of the insecticide lindane. Am J Ind Med 1998; 33: 82-7.
  • Quintana PJE, Delfino RJ, Korrick S, et al. Adipose tissue levels of organochlorine pesticides and chlorinated biphenyls and the risk of non-Hodgkin’s lymphoma. Environ Health Perspect 2004; 112: 854-61.
  • Brauner EV, Sorensen MA, Gaudreau E, et al. A prospective study of organochlorines in adipose tissue and risk of non-Hodgkin lymphoma. Environ Health Perspect 2012; 120(1): 105-11.
  • Rothman N, Cantor KP, Blair A, et al. A nested case control study of non Hodgkin lymphoma and serum organochlorine residues. Lancet 1997; 350: 240-4.
  • Alavanja M, Bonner M. Occupational pesticide exposure and cancer risk. A Review. J Toxicol Environ Health Critic Review 2012; 1594: 238-63.
  • Alavanja MCR, Ross MK, Bonner MR. Increased cancer burden among pesticide applicators and others due to pesticide exposure. Cancer J Clin 2013; 63(2): 120-42.
  • Abdollahi M, Mostafalou S, Pournourmohammadi, S, Shadnia S. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion. Comp Biochem Physiol 2004; 137: 29-34.
  • Galloway T, Handy R. Immunotoxicity of organophosphorous pesticides. Ecotoxicology 2003; 12: 345-63.
  • Chiu BC, Dave BJ, Blair A, Gapstur SM, Zahm SH, Weisenburger DD. Agricultural pesticide use and risk of defined subtypes of non-Hodgkin lymphoma. Blood 2006; 108: 1363-9.
  • Schroeder JC, Olshan AF, Baric R, et al. Agricultural risk factors for subtypes of non-Hodgkin’s lymphoma. Epidemiology 2001; 12: 701-9.
  • Zahm SH, Weisenburger DD, Saal RC, Vaught JB, Babbitt PA, Blair A. The role of agricultural pesticide use in the development of non-Hodgkin’s lymphoma in women. Arch Environ Health 1993; 48(5): 353-8.
  • Jones RR, Yu CL, Nuckols JR, et al. Farm residence and lymphohematopoietic cancers in the Iowa Women’s Health Study. Environ Res 2014; 133: 353-61.

Lenfoma etiyolojisinde pestisitlerin rolü: Sistematik derleme

Yıl 2020, Cilt: 12 Sayı: 2, 142 - 150, 01.06.2020
https://doi.org/10.21601/ortadogutipdergisi.639830

Öz

Amaç: Tarım çalışanlarında non-Hodgkin lenfoma riskinin arttığı bilinmektedir ve bu artışta pestisitlerin rolü olduğu düşünülmektedir. Bu sistematik derlemenin amacı lenfoma etiyolojisinde pestisitlerin rolünü ve etkisini değerlendirmektir.
Gereç ve Yöntemler: Bu sistematik derleme York Üniversitesi Ulusal Sağlık Araştırmaları Enstitüsü tarafından geliştirilen Derleme ve Yaygınlaştırma Merkezi 2009 kılavuzuna uygun olarak yürütülmüştür. Çalışmaya ilişkin taramalar 2014-2019 yıllarını kapsayacak şekilde Science Direct, EBSCO (CINAHL Complete), PUBMED, Wiley Interscience ve Springer Link veri tabanlarında yapılmıştır.
Bulgular: Tarama sonucunda, kriterlere uyan altı çalışma araştırma kapsamında alınmıştır. Sonuçlar “Çalışmanın yılı, araştırma tipi ve örneklem özellikleri, kullanılan ölçüm araçları, elde edilen sonuçlar ve kanıt düzeyi” başlıkları altında tablo olarak sunulmuştur.
Sonuç: Pestisit kullanımının non-Hodgkin lenfoma ve alt tipleri ile ilişkili olduğu bulunmuştur. Tarımın ana geçim kaynağı olduğu toplumlarda mesleki maruziyet değerlendirilmeli ve bu grup kişisel koruyucu ekipman kullanımı ve koruyucu davranışlar konularında sağlık profesyonelleri tarafından eğitilmelidir.

Kaynakça

  • https://acikders.ankara.edu.tr/pluginfile.php/62780/mod_resource/content/0/4.pdf (Accessed September 26, 2019).
  • Blair A, Dosemeci M, Heineman EF. Cancer and other causes of death among male and female farmers from twenty-three states. Am J Ind Med 1993; 23(5): 729-42.
  • Blair A, Zahm SH. Agricultural exposures and cancer. Environ Health Perspect 1995; 103(8 Suppl): 205-8.
  • Keller-Byrne JE, Khuder SA, Schaub EA, McAfee O. Ameta-analysis of non-Hodgkin’s lymphoma among farmers in the central United States. Am J Ind Med 1997; 31(4): 442-4.
  • Khuder SA, Schaub EA, Keller-Byrne JE. Meta-analyses of non-Hodgkin’s lymphoma and farming. Scand J Work Environ Health 1998; 24(2): 255-61.
  • Schinasi LH, De Roos AJ, Ray RM, et al. insecticide exposure and farm history in relation to risk of lymphomas and leukemias in the Women’s Health Initiative observational study cohort. Annals of Epidemiology 2015; 25: 803-10.
  • Guyton KZ, Loomis D, Grosse Y, et al. Carcinogenicity of pentachlorophenol and some related compounds. Lancet Oncol 2016; 17: 1637-8.
  • Loomis D, Guyton K, Grosse Y, et al. Carcinogenicity of lindane, DDT, and 2,4-dichlorophenoxyacetic acid. Lancet Oncol 2015; 16: 891-2.
  • Engel LS, Laden F, Andersen A, et al. Polychlorinated biphenyl levels in peripheral blood and non-Hodgkin’s lymphoma: a report from three cohorts. Cancer Res 2007; 67: 5545-52.
  • De Roos AJ, Hartge P, Lubin JH, et al. Persistent organochlorine chemicals in plasma and risk of non-Hodgkin’s lymphoma. Cancer Res 2005; 65: 11214-26.
  • Colt JS, Rothman N, Severson RK, et al. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Blood 2009; 113: 1899-905.
  • Freeman MD, Kohles SS. Plasma levels of polychlorinated biphenyls, non-Hodgl,n lymphoma, and causation. J Environ Public Health 2012: 258981.
  • Laden F, Bertrand KA, Altshol L, Aster JC, Korrick SA, Sagiy SK. Plasma organochlorine levels and risk of non-Hodgkin lymphoma in the Nurses’ Health Study. Cancer Epidemiol Biomark Prev 2010; 19: 1381-4.
  • Cocco P, Brennan P, Ibba A, et al. Plasma polychlorobiphenyl and organochlorine pesticide level and risk of major lymphoma subtypes. Occup Environ Med 2008; 65: 132-40.
  • Zani C, Ceretti E, Covolo L, Donato F. Do polychlorinated biphenyl cause cancer? A systematic review and meta-analysis of epidemiological studies on risk of cutaneous melanoma and non-Hodgkin lymphoma. Chemosphere 2017; 183: 97-106.
  • Blair A, Ritz B, Wesseling C, Freeman LB. Pesticides and human health. Occup Environ Med 2015; 72: 81-2.
  • Koutros S, Beane Freeman LE, Lubin JH, et al. Risk of total and aggressive prostate cancer and pesticide use in the Agricultural Health Study. Am J Epidemiol 2013; 177: 59-74.
  • International Agency for Research on Cancer (IARC). Malathion. 112 IARC, Lyon, France. 2015. https://www.iarc.fr/wp-content/uploads/2018/07/Mono graphVolume112-1.pdf (Accessed September 27, 2019).
  • Alavanja MC, Hofmann JN, Lynch CF, et al. Non-hodgkin lymphoma risk and insecticide, fungicide and fumigant use in the agricultural health study. PLoS One 2014; 9: e109332.
  • Bonner MR, Williams BA, Rusiecki JA, et al. Occupational exposure to terbufos and the incidence of cancer in the Agricultural Health Study. Cancer Causes Control 2010; 21: 871-7.
  • Fineout-Overholt E, Melnyk BM, Stillwell SB, Williamson KM. Evidence-based practice step by step: critical appraisal of the evidence: part I. Am J Nurs 2010; 110(7): 47-52.
  • Moher D, Liberati A, Tetzlaff J, et al. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. Ann Intern Med 2009; 151(4): 264-9.
  • Ferri MA, Specchia G, Mazza P, et al. risk of lymphoma subtypes by occupational exposure in Southern Italy. J Occup Med Toxicol 2017; 12(31): 1-10.
  • Koutros S, Harris SA, Spinelli JJ, et al. Non-Hodgkin lymphoma risk and organophosphate and carbamate insecticide use in the North American pooled project. Environ Int 2019; 127: 199-205.
  • Bassig BA, Shu XO, Sjödin A, et al. Prediagnostic blood levels of organochlorines and risk of non-Hodgkin lymphoma in three prospective cohorts in China and Singapore. Int J Cancer 2019: 1-11.
  • Klil-Drori AJ, Kleinstern G, Seir RA, et al. Serum organochlorines and non-Hodgkin lymphoma: a case control study in Israeli Jews and Palestinians. Chemosphere 2018; 213: 395-402.
  • Purdue MP, Hoppin JA, Blair A, Dosemeci M, Alavanja MCR. Occupational exposure to organochlorine insecticides and cancer incidence in the Agricultural Health Study. Int J Cancer 2007; 120(3): 642-9.
  • Environmental Protection Agency (EPA). DDT-A Brief History and Status. 2012. http://www.epa.gov/pestici des/factsheets/chemicals/ddt-brief-history-status.htm (Accessed October 1, 2019).
  • Stockholm Convention Report. Report of the conference of the Parties of the Stockholm Convention on Persistent Organic Pollutants on the work of its 4th meeting. Fourth Meeting, Geneva, 2009. http://chm.pops.int/Portals/0/ Repository/COP4/UNEP-POPS-COP.4-38.English.pdf (Accessed September 25, 2019).
  • National Pesticide Information Center (NPIC). Chemicals Evaluated for Carcinogenic Potential, Office of Pesticide Programs. U.S. Environmental Protection Agency. 2012. http://npic.orst.edu/chemicals_evaluated.pdf (Accessed September 29, 2019).
  • Environmental Protection Agency (EPA). Re-registration Eligibility Decision for Terbufos. 2006. http://www.epa. gov/pesticides/reregistration/REDs/terbufos_red.pdf (Accessed October 2, 2019).
  • Cantor KP, Blair A, Everett G, et al. Pesticides and other agricultural risk factors for non-Hodgkin’s lymphoma among men in Iowa and Minnesota. Cancer Res 1992; 52: 2447-55.
  • Waddell BL, Zahm SH, Baris D, et al. Agricultural use of organophosphate pesticides and the risk of non-Hodgkin’s lymphoma among male farmers (United States). Cancer Causes Control 2001; 12: 509-17.
  • McDuffie HH, Pahwa P, McLaughlin JR, et al. Non-Hodgkin’s lymphoma and specific pesticide exposures in men: cross-Canada study of pesticides and health. Cancer Epidemiol Biomark Prev 2001; 10: 1155-63.
  • National Toxicological Program. Captafol. Rep Carcinog 2011; 12: 83-6.
  • Park SK, Kang D, Beane-Freeman L, et al. Cancer incidence among Paraquat exposed pesticide applicators in the agricultural health study. Int J Occup Environ Health 2009; 15(3): 274-81.
  • Rudyk C, Litteljohn D, Syed S, Dwyer Z, Hayley S. Paraquat and psychological stressor interactions as pertains to Parkinsonian co-morbidity. Neurobiol Stress 2015; 2: 85-93.
  • Blair A, Cantor KP, Zahm SH. Non-Hodgkin’s lymphoma and agricultural use of the insecticide lindane. Am J Ind Med 1998; 33: 82-7.
  • Quintana PJE, Delfino RJ, Korrick S, et al. Adipose tissue levels of organochlorine pesticides and chlorinated biphenyls and the risk of non-Hodgkin’s lymphoma. Environ Health Perspect 2004; 112: 854-61.
  • Brauner EV, Sorensen MA, Gaudreau E, et al. A prospective study of organochlorines in adipose tissue and risk of non-Hodgkin lymphoma. Environ Health Perspect 2012; 120(1): 105-11.
  • Rothman N, Cantor KP, Blair A, et al. A nested case control study of non Hodgkin lymphoma and serum organochlorine residues. Lancet 1997; 350: 240-4.
  • Alavanja M, Bonner M. Occupational pesticide exposure and cancer risk. A Review. J Toxicol Environ Health Critic Review 2012; 1594: 238-63.
  • Alavanja MCR, Ross MK, Bonner MR. Increased cancer burden among pesticide applicators and others due to pesticide exposure. Cancer J Clin 2013; 63(2): 120-42.
  • Abdollahi M, Mostafalou S, Pournourmohammadi, S, Shadnia S. Oxidative stress and cholinesterase inhibition in saliva and plasma of rats following subchronic exposure to malathion. Comp Biochem Physiol 2004; 137: 29-34.
  • Galloway T, Handy R. Immunotoxicity of organophosphorous pesticides. Ecotoxicology 2003; 12: 345-63.
  • Chiu BC, Dave BJ, Blair A, Gapstur SM, Zahm SH, Weisenburger DD. Agricultural pesticide use and risk of defined subtypes of non-Hodgkin lymphoma. Blood 2006; 108: 1363-9.
  • Schroeder JC, Olshan AF, Baric R, et al. Agricultural risk factors for subtypes of non-Hodgkin’s lymphoma. Epidemiology 2001; 12: 701-9.
  • Zahm SH, Weisenburger DD, Saal RC, Vaught JB, Babbitt PA, Blair A. The role of agricultural pesticide use in the development of non-Hodgkin’s lymphoma in women. Arch Environ Health 1993; 48(5): 353-8.
  • Jones RR, Yu CL, Nuckols JR, et al. Farm residence and lymphohematopoietic cancers in the Iowa Women’s Health Study. Environ Res 2014; 133: 353-61.
Toplam 49 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Sağlık Kurumları Yönetimi
Bölüm Araştırma makaleleri
Yazarlar

Derya Adıbelli 0000-0001-9320-7083

Yayımlanma Tarihi 1 Haziran 2020
Yayımlandığı Sayı Yıl 2020 Cilt: 12 Sayı: 2

Kaynak Göster

Vancouver Adıbelli D. The role of pesticides in the etiology of lymphoma: A systematic review. otd. 12(2):142-50.

e-ISSN: 2548-0251

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